When Is Mlb Opening Day 2025 Sf Giants. 18—the cincinnati reds will play the san francisco giants on march 27, 2025, at great american ball park on opening day in cincinnati. Giants alumni and broadcasters are expected to attend the event, along with current players who will “pop in” from scottsdale to interact with fans via a hologram booth at oracle.
Here’s a look at the giants’ most notable dates: The 2025 campaign gets underway in the queen city of cincinnati.